Tag: dose optimization

  • Clinical Dose Optimization

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    Alicia
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    In Oncology In oncology, dose finding trials started using 3+3 dose escalation/expansion to select the recommended phase 2 dose (RP2D) and determine the maximum tolerated dose (MTD) in the 1990s. The earliest treatments for cancer – cytotoxic chemotherapies – had a steep dose-response curve and limited drug target specificity. Due to the lack of available…